Degredation of insulin by a particulate fraction from adipose tissue
نویسندگان
چکیده
منابع مشابه
Insulin Degradation by Adipose Tissue
A systematic study of the degradation of physiological concentrations of 125I-labelled insulin was performed in intact fat-pads, isolated adipocytes and subcellular fractions of isolated adipocytes. The findings indicate that insulin is rapidly degraded to low-molecular-weight peptides and/or amino acids by the intact tissue and isolated cells. Of the total insulin-degradation products present ...
متن کاملAdipose tissue ELVs induce insulin resistance Adipose tissue exosome-like vesicles mediate activation of macrophage- induced insulin resistance A running title: Adipose tissue ELVs induce insulin resistance
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294; Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL 35294 Department of Nutrition, University of Alabama at Birmingham, Birmingham, AL 35294 ...
متن کاملThe Oxidation of Thiocyanate by a Cytoplasmic Particulate Fraction of Thyroid Tissue.
Thiocyanate, a ubiquitous anion in the body, inhibits the concentration of iodide by the thyroid and the iodination of tyrosine in this tissue (1, 2). This pseudohalide is oxidized by thyroid tissue in viva (3-6). Sulfate is the major sulfur product. This report will describe a cytoplasmic particulate system derived from mammalian thyroid tissue that oxidizes thiocyanate ion in vitro to product...
متن کاملQuantification of adipose tissue insulin sensitivity.
In metabolically healthy humans, adipose tissue is exquisitely sensitive to insulin. Similar to muscle and liver, adipose tissue lipolysis is insulin resistant in adults with central obesity and type 2 diabetes. Perhaps uniquely, however, insulin resistance in adipose tissue may directly contribute to development of insulin resistance in muscle and liver because of the increased delivery of fre...
متن کاملMetabolic and Ultrastructural Changes Induced in Adipose Tissue by Insulin
The addition in vitro of insulin to rat adipose tissue (epididymal) produces marked metabolic changes which may be followed by measurement of the net gas exchange of the tissue. Using this method to monitor the metabolic action of insulin, concomitant observations with the electron microscope on the tissue have been made. These reveal that pronounced morphological changes are induced by insulin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1970
ISSN: 0306-3283
DOI: 10.1042/bj1160825